Phloretin is widely used in skincare and cosmetic formulations due to its strong antioxidant properties. It helps protect the skin from oxidative stress and environmental damage, particularly from UV radiation, which can accelerate aging. It is also known to inhibit glucose transporters in the skin, which may support brightening effects and improve the efficacy of other active ingredients by enhancing their penetration. In addition to topical applications, phloretin is studied for its anti-inflammatory and antimicrobial activities, making it useful in products targeting acne and irritated skin. It is often combined with other antioxidants like vitamin C and ferulic acid to boost overall stability and performance in serums and creams. Phloretin also shows promise in pharmaceutical research for its potential to support metabolic health and exhibit anticancer activity, mainly through its ability to induce cell cycle arrest and apoptosis in abnormal cells. However, these applications are still under investigation and primarily limited to preclinical studies.