Picroside II is widely recognized for its neuroprotective properties, making it a subject of interest in the treatment of neurological disorders. It has shown potential in protecting brain cells from damage caused by oxidative stress and inflammation, particularly in conditions like cerebral ischemia and Alzheimer’s disease. Its ability to cross the blood-brain barrier enhances its effectiveness in targeting central nervous system pathologies.

It is also valued for its hepatoprotective effects, helping to safeguard the liver from toxins and reducing markers of liver damage in various experimental models. This makes it useful in supporting liver health and in the development of treatments for liver diseases such as hepatitis and drug-induced hepatotoxicity.

Additionally, Picroside II exhibits anti-inflammatory and antioxidant activities, which contribute to its therapeutic role in managing chronic inflammatory conditions and reducing cellular damage caused by free radicals. Due to these combined effects, it is being explored as a natural compound in herbal medicine formulations, especially in traditional systems like Ayurveda, for improving cognitive function and supporting overall cellular resilience. It is primarily extracted from the rhizomes of the plant Picrorhiza kurroa.