Picroside I is widely used in the pharmaceutical industry due to its significant neuroprotective and hepatoprotective properties. It is commonly employed in the development of drugs targeting liver disorders, including hepatitis and liver fibrosis, where it helps reduce oxidative stress and inflammation. Its ability to scavenge free radicals makes it valuable in formulations aimed at protecting neural tissues, particularly in ischemic stroke and neurodegenerative conditions like Alzheimer’s and Parkinson’s disease. Additionally, Picroside I exhibits anti-inflammatory and anti-apoptotic effects, supporting its use in treating cerebral ischemia and cardiovascular injuries. It is also explored in herbal medicine standardization, especially in preparations derived from Picrorhiza kurroa, a plant used in traditional medicine for immune modulation and detoxification.