Used primarily in research related to pain management and sensory neuron studies due to its ability to activate TRPV1 receptors, which are involved in the perception of heat and pain. It is also utilized in the development of topical analgesics and counterirritants for temporary relief of muscle and joint pain. Its presence in some pepper extracts makes it relevant in the formulation of self-defense sprays and animal repellents. Additionally, it serves as a reference standard in analytical testing of capsaicinoids in pharmaceuticals and natural products.