Nobiletin is widely studied for its potential health benefits, particularly in supporting brain and metabolic health. It has shown promise in improving cognitive function and may help protect against neurodegenerative diseases like Alzheimer’s by reducing inflammation and preventing the buildup of harmful proteins in the brain. It also exhibits anti-diabetic properties by enhancing insulin sensitivity and regulating blood sugar levels. Research indicates nobiletin can support cardiovascular health by lowering bad cholesterol and reducing plaque formation in arteries. In addition, nobiletin has demonstrated anti-cancer activity in laboratory studies, where it was found to inhibit the growth and spread of certain tumor cells, especially in colon, breast, and liver cancers. Due to its anti-inflammatory and antioxidant effects, it is being explored for use in dietary supplements and functional foods aimed at promoting longevity and preventing chronic diseases.