Nobiletin is widely studied for its potential health benefits, particularly in supporting brain and metabolic health. It has shown promise in improving cognitive function and may help protect against neurodegenerative diseases like Alzheimer’s by reducing inflammation and preventing the buildup of harmful proteins in the brain. Research also indicates that nobiletin supports metabolic health by helping regulate blood sugar levels and improving insulin sensitivity, making it of interest in managing type 2 diabetes. It has been found to activate pathways involved in fat metabolism, which may help reduce obesity and fatty liver disease. Additionally, nobiletin exhibits anti-inflammatory and antioxidant properties, contributing to its potential in cancer prevention and cardiovascular protection. Most of the current evidence comes from animal and cell studies, and further human trials are needed to confirm these effects.