Monotropein is widely studied for its anti-inflammatory and antioxidant properties, making it valuable in the development of therapeutic agents for chronic inflammatory diseases. It has shown potential in inhibiting key inflammatory pathways, such as NF-κB and MAPK, which are involved in conditions like arthritis and inflammatory bowel disease. Research also indicates neuroprotective effects, suggesting possible use in treating neurodegenerative disorders such as Alzheimer's disease. Additionally, monotropein exhibits antidiabetic activity by improving insulin sensitivity and protecting pancreatic β-cells. Its ability to modulate oxidative stress further supports its role in hepatoprotective applications, where it helps reduce liver damage caused by toxins or metabolic disorders. These diverse biological activities make monotropein a promising candidate for natural product-based drug development.