Monotropein is widely studied for its anti-inflammatory and antioxidant properties, making it a compound of interest in the development of natural therapeutics for chronic inflammatory diseases. It has shown potential in inhibiting key inflammatory pathways, such as NF-κB and MAPK, which are involved in conditions like arthritis and inflammatory bowel disease. Research also indicates neuroprotective effects, suggesting possible use in treating neurodegenerative disorders such as Alzheimer’s disease. Additionally, monotropein exhibits antidiabetic activity by improving insulin sensitivity and reducing blood glucose levels in preclinical models. Its ability to modulate oxidative stress further supports its role in hepatoprotection and cardiovascular health. Due to these diverse biological activities, monotropein is being explored as a lead compound in herbal medicine and nutraceutical formulations.