Koumine is primarily studied for its potential neuroprotective and anti-inflammatory effects. It has shown promise in modulating neurotransmitter systems, particularly those involved in pain perception and mood regulation, making it a candidate for research in analgesic and anxiolytic therapies. Studies suggest koumine may help reduce neuropathic pain and anxiety-like behaviors in animal models, possibly through interaction with the GABAergic and monoaminergic systems. It is also being explored for its potential in managing depression and addiction due to its influence on dopamine and opioid pathways. Additionally, koumine exhibits anti-tumor properties in preclinical studies, where it has been observed to inhibit proliferation and induce apoptosis in certain cancer cell lines. Its ability to cross the blood-brain barrier enhances its suitability for central nervous system-related therapeutic development. However, most applications remain in the experimental stage, requiring further validation before clinical use.