Helichrysetin is a flavonoid compound utilized in biochemical research for its potent anti-inflammatory and antioxidant properties. It demonstrates significant potential in inhibiting the proliferation of certain cancer cells, including colon and breast cancer, via mechanisms such as inducing apoptosis and suppressing inflammatory pathways like NF-κB. In skincare formulations, it serves as an antioxidant to protect skin cells from oxidative stress and environmental damage, with applications in anti-aging products to support cellular health. It is also explored for natural anti-inflammatory treatments in topical applications to soothe irritated skin, antimicrobial activity for preservative systems or acne treatments, and promoting wound healing while enhancing skin barrier function. As a plant-derived intermediate, it holds promise for developing alternative therapies and natural supplements.