Fisetin is a natural flavonoid found in various fruits and vegetables, known for its antioxidant properties. It is widely studied for its potential health benefits, particularly in aging and neurodegenerative diseases. Fisetin acts as a senolytic agent, meaning it helps clear aged or damaged cells (senescent cells) from the body, which may contribute to increased lifespan and improved tissue function. This property makes it a promising candidate in anti-aging research and age-related conditions such as arthritis, cardiovascular disease, and diabetes. It also supports brain health by promoting neuronal survival and enhancing memory and cognitive function in preclinical models. Research suggests fisetin may help protect against neurodegenerative disorders like Alzheimer’s and Parkinson’s diseases by reducing inflammation and oxidative stress in brain tissues. In addition, fisetin exhibits anti-inflammatory effects and modulates key cellular pathways involved in cell growth and survival, drawing interest for its potential role in cancer prevention and as an adjunct in cancer therapy. Due to its ability to influence multiple signaling pathways, it is also being explored for metabolic health, including insulin sensitivity and glucose regulation. While most evidence comes from cell and animal studies, fisetin is available as a dietary supplement, primarily marketed for cognitive support and longevity. Ongoing research aims to confirm its efficacy and safety in humans.