Daphnetin is widely studied for its anti-inflammatory and antioxidant properties, making it valuable in pharmaceutical and cosmetic applications. It is used in the development of drugs targeting inflammatory diseases such as arthritis and dermatitis due to its ability to inhibit pro-inflammatory cytokines and enzymes like COX-2. Its antioxidant activity helps protect cells from oxidative stress, which is beneficial in neurodegenerative disorder research, including Alzheimer’s and Parkinson’s diseases. In dermatology, daphnetin is incorporated into skincare formulations for its skin-whitening and UV-protective effects. It inhibits tyrosinase activity, reducing melanin production, which helps in treating hyperpigmentation. Additionally, it shows antimicrobial activity against certain pathogens, supporting its use in topical antiseptics and wound healing products. Emerging research also explores daphnetin’s potential as an anticancer agent, where it demonstrates the ability to induce apoptosis and suppress tumor cell proliferation in various cancer cell lines. Its low toxicity and natural origin enhance its appeal for use in nutraceuticals and functional foods aimed at disease prevention.