Cepharanthine is primarily used in research for its anti-inflammatory, antiviral, and anticancer properties. It has shown potential in modulating multidrug resistance in cancer cells by inhibiting efflux pumps, thereby enhancing the effectiveness of certain chemotherapeutic agents. Studies also indicate its ability to suppress pro-inflammatory cytokines, making it a candidate for managing inflammatory conditions. Recently, it has drawn attention for its antiviral activity against several viruses, including SARS-CoV-2, by interfering with viral entry and replication processes. Additionally, cepharanthine exhibits radioprotective effects and has been explored for use in reducing damage from radiation exposure. Most applications remain in the preclinical research stage, with ongoing studies to evaluate its therapeutic potential and safety profile.