d-Bicuculline
Analytical reference substance, ≥99% (HPLC)
Reagent
Code: #143183
Alias
Dextrophic biquorine;(+)-Baiduinine, Biquorine, Dextrophic biquorine, Biquorine, Biquorine, Shantulin
CAS Number
485-49-4
science Other reagents with same CAS 485-49-4
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Molecular Information
Weight
367.35 g/mol
Formula
C₂₀H₁₇NO₆
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Registry Numbers
EC Number
207-619-7
MDL Number
MFCD00005006
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Physical Properties
Melting Point
193-197 °C
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Storage & Handling
Storage
2-8°C
description Product Description
Used primarily in neuroscience research to study the function of GABA_A receptors. Acts as a competitive antagonist at GABA_A receptors, blocking the inhibitory effects of GABA, the main inhibitory neurotransmitter in the central nervous system. This blockade leads to increased neuronal excitability, making it a valuable tool for inducing seizures in experimental models to study epilepsy. Also used to investigate synaptic transmission, neural circuitry, and the role of inhibitory signaling in behavior and brain function. Due to its potent convulsant properties, it is not used therapeutically but remains important in laboratory settings for probing the mechanisms of inhibition and excitation in the brain.
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