WILFORGINE is an alkaloid found in plants of the Celastraceae family, particularly Tripterygium wilfordii, a traditional Chinese medicinal herb. It is primarily studied for its potential therapeutic applications in traditional medicine and modern pharmacology. It is often explored for its anti-inflammatory and immunosuppressive properties, making it a candidate for treating autoimmune disorders such as rheumatoid arthritis and inflammatory conditions. Research has also investigated its role in inhibiting tumor growth, suggesting possible applications in cancer therapy. Additionally, WILFORGINE has been examined for its effects on the nervous system, with studies indicating potential benefits in managing neuropathic pain or neurological disorders. In traditional Chinese medicine, it is used for skin diseases, gout, and chronic pain. Its use in traditional herbal remedies highlights its historical significance in treating various ailments. However, due to potential side effects and toxicity, its use should be under medical supervision. Further clinical studies are needed to validate its efficacy and safety.