Sinomenine hydrochloride is widely used in the treatment of rheumatoid arthritis due to its anti-inflammatory and immunosuppressive properties. It helps reduce joint swelling, pain, and stiffness, improving mobility in patients. Additionally, it is studied for its potential in managing other autoimmune diseases and chronic inflammatory conditions. Its ability to modulate immune responses makes it a valuable component in therapeutic research. It is also explored for its neuroprotective effects, showing promise in treating neurodegenerative disorders. In traditional medicine, it has been utilized for its analgesic and sedative properties, further broadening its applications in modern pharmacology.