Rutaecarpine is an indole alkaloid widely studied for its potential therapeutic applications in traditional medicine and modern pharmacology. It exhibits vasodilatory effects, making it useful in managing cardiovascular conditions such as hypertension by promoting blood vessel relaxation, improving blood flow, and reducing blood pressure. Additionally, it possesses anti-inflammatory, analgesic, and antioxidant properties, positioning it as a candidate for treating pain, inflammatory disorders, and oxidative stress-related conditions. Rutaecarpine also modulates thermogenesis and energy expenditure, sparking interest in metabolic and weight management applications. Research suggests neuroprotective benefits for neurodegenerative diseases and potential anti-cancer effects through inhibition of tumor cell growth. Ongoing studies continue to explore its broader pharmacological potential.