2-(2,6-Dioxopiperidin-3-yl)-5,6-difluoroisoindoline-1,3-dione

98%

Reagent Code: #82315
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CAS Number 1496997-41-1

science Other reagents with same CAS 1496997-41-1

blur_circular Chemical Specifications

scatter_plot Molecular Information
Weight 294.21 g/mol
Formula C₁₃H₈F₂N₂O₄
inventory_2 Storage & Handling
Storage 2-8°C, dry, sealed

description Product Description

This compound is a thalidomide analog primarily utilized in the development of pharmaceuticals, particularly immunomodulatory drugs (IMiDs) for cancer therapy, such as multiple myeloma. It serves as a key intermediate in the synthesis of cereblon ligands that induce the ubiquitination and subsequent proteasomal degradation of target proteins, like transcription factors, in cancer cells. This mechanism disrupts the growth and survival of malignant cells, making it valuable in oncology research. Additionally, it has potential applications in the study of neurodegenerative diseases, where targeted protein degradation pathways play a significant role. Its unique chemical structure enables specific interactions with E3 ubiquitin ligases, contributing to advancements in therapeutic drug development, including PROTACs and other protein degraders.

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Test Parameter Specification
Appearance Black Solid
Purity (%) 97.5-100
Infrared Spectrum Conforms to Structure
NMR Conforms to Structure

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Size Availability Unit Price Quantity
inventory 250mg
10-20 days ฿3,141.00
inventory 1g
10-20 days ฿7,911.00

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2-(2,6-Dioxopiperidin-3-yl)-5,6-difluoroisoindoline-1,3-dione
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This compound is a thalidomide analog primarily utilized in the development of pharmaceuticals, particularly immunomodulatory drugs (IMiDs) for cancer therapy, such as multiple myeloma. It serves as a key intermediate in the synthesis of cereblon ligands that induce the ubiquitination and subsequent proteasomal degradation of target proteins, like transcription factors, in cancer cells. This mechanism disrupts the growth and survival of malignant cells, making it valuable in oncology research. Additional

This compound is a thalidomide analog primarily utilized in the development of pharmaceuticals, particularly immunomodulatory drugs (IMiDs) for cancer therapy, such as multiple myeloma. It serves as a key intermediate in the synthesis of cereblon ligands that induce the ubiquitination and subsequent proteasomal degradation of target proteins, like transcription factors, in cancer cells. This mechanism disrupts the growth and survival of malignant cells, making it valuable in oncology research. Additionally, it has potential applications in the study of neurodegenerative diseases, where targeted protein degradation pathways play a significant role. Its unique chemical structure enables specific interactions with E3 ubiquitin ligases, contributing to advancements in therapeutic drug development, including PROTACs and other protein degraders.

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