This chemical is primarily used in photoaffinity labeling, a technique employed in biochemical research to study protein-ligand interactions. The 4-(iodomethyl)phenyl group provides a reactive handle for conjugation to ligands or biomolecules via nucleophilic substitution (e.g., with amines or thiols). When exposed to ultraviolet light, the diazirine moiety generates highly reactive carbene intermediates that can form covalent bonds with nearby molecules, allowing researchers to identify and map binding sites on proteins. It is particularly valuable in drug discovery and proteomics for understanding molecular interactions at a detailed level. Additionally, its trifluoromethyl group enhances stability and reactivity, making it a preferred choice in such applications.