Used as a key reagent in organic synthesis, particularly in the preparation of phosphate esters and nucleotides. It plays a significant role in the phosphorylation of alcohols, sugars, and nucleosides, which is essential in the development of pharmaceuticals and biochemical compounds. Additionally, it is employed in the synthesis of prodrugs and in modifying biomolecules for research purposes. Its application extends to the production of agrochemicals and specialty chemicals, where precise phosphorylation is required.