Used as a reagent in organic synthesis, particularly in the preparation of phosphoramidite monomers for oligonucleotide synthesis. It enables the introduction of phosphite triester linkages in DNA and RNA building blocks, which are essential in the solid-phase synthesis of nucleic acids for research, diagnostics, and therapeutic applications. Its bulky tert-butyl and isopropyl groups help reduce side reactions and improve selectivity during coupling steps. Commonly employed in the development of antisense oligonucleotides, siRNA, and other nucleic acid-based drugs.