Used as a key reagent in organic synthesis, particularly in the preparation of phosphonate-containing compounds that serve as intermediates in pharmaceuticals and agrochemicals. It plays an important role in the synthesis of α-aminophosphonates through aza-Darboux type reactions or related cycloadditions, which are structural analogs of amino acids with biological activity. Its isocyano group enables participation in multicomponent reactions, facilitating the construction of complex nitrogen- and phosphorus-containing molecules. Commonly applied in medicinal chemistry for developing enzyme inhibitors and antimicrobial agents. Also utilized in the design of novel ligands for catalysis due to its ability to form stable derivatives with transition metals.