Diethyl (1-oxo-1-phenylpropan-2-yl)phosphonate
96%
Reagent
Code: #129461
CAS Number
10409-56-0
blur_circular Chemical Specifications
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Molecular Information
Weight
270.26 g/mol
Formula
C₁₃H₁₉O₄P
thermostat
Physical Properties
Boiling Point
156.5-158 °C at 1.5 mmHg
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Storage & Handling
Density
1.1328 g/cm3
Storage
Room temperature, seal, inert gas
description Product Description
Used as a key intermediate in the synthesis of α,β-unsaturated carbonyl compounds through the Horner-Wadsworth-Emmons (HWE) olefination reaction. It enables the selective formation of trans-configured enones when reacted with aldehydes under basic conditions. Its phosphonate group stabilizes the carbanion, facilitating carbon-carbon bond formation in pharmaceutical and fine chemical manufacturing. Particularly valuable in constructing conjugated systems found in bioactive molecules and natural product analogs. Shows good reactivity with aromatic and aliphatic aldehydes, making it versatile in organic synthesis.
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