GSK-269984A is primarily used in research settings as a potent and selective inhibitor of the enzyme phosphodiesterase 10A (PDE10A). Its application is significant in neuroscience studies, particularly in understanding the role of PDE10A in the brain. Researchers utilize this compound to investigate its effects on signaling pathways associated with neurological disorders such as schizophrenia, Huntington's disease, and Parkinson's disease. By inhibiting PDE10A, GSK-269984A helps in studying the modulation of cyclic nucleotides like cAMP and cGMP, which are crucial for neuronal function. This makes it a valuable tool for exploring potential therapeutic strategies for these conditions. Additionally, it aids in the development of new pharmacological agents targeting PDE10A for improved treatment options.