Ibudilast is primarily used in the treatment of asthma and cerebrovascular disorders. It works by inhibiting phosphodiesterase, which helps in reducing inflammation and improving blood flow. In recent years, it has gained attention for its potential in managing neurodegenerative diseases, such as multiple sclerosis and amyotrophic lateral sclerosis (ALS), due to its anti-inflammatory and neuroprotective properties. Additionally, ibudilast is being studied for its effectiveness in treating chronic pain and substance abuse disorders, particularly opioid addiction, as it may help reduce withdrawal symptoms and cravings. Its ability to modulate glial cell activity makes it a promising candidate for addressing various conditions involving neuroinflammation.