CZC-25146 is primarily used in research settings as a potent and selective inhibitor of the enzyme phosphodiesterase 10A (PDE10A). Its application is significant in studying neurological disorders, particularly those related to dopamine signaling, such as schizophrenia and Huntington's disease. By inhibiting PDE10A, CZC-25146 helps modulate intracellular signaling pathways, providing insights into the role of this enzyme in brain function and potential therapeutic targets. It is also utilized in preclinical studies to evaluate the effects of PDE10A inhibition on behavior, cognition, and motor control, contributing to the development of novel treatments for psychiatric and neurodegenerative conditions.