TAS4464 hydrochloride is primarily used in pharmaceutical research and development as a potent and selective inhibitor of phosphodiesterase 2A (PDE2A). Its main application lies in the investigation of cognitive disorders and neurodegenerative diseases such as Alzheimer's disease. By inhibiting PDE2A, it increases intracellular levels of cyclic nucleotides like cAMP and cGMP, which are involved in memory formation and synaptic plasticity. This makes TAS4464 hydrochloride a valuable tool compound for studying pathways related to learning and memory. It has also been explored for potential effects on mood and motivation in preclinical models, suggesting possible relevance in treating aspects of depression or cognitive impairment associated with psychiatric disorders. Due to its blood-brain barrier permeability, it is particularly suited for in vivo studies targeting central nervous system functions.