PF-3716556
10mM in DMSO
Reagent
Code: #223988
CAS Number
928774-43-0
blur_circular Chemical Specifications
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Molecular Information
Weight
394.47 g/mol
Formula
C₂₂H₂₆N₄O₃
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Registry Numbers
MDL Number
MFCD19690947
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Storage & Handling
Storage
-20°C
description Product Description
Used in research as a potent and selective inhibitor of phosphodiesterase 10A (PDE10A), making it a valuable tool compound for studying neurological and psychiatric disorders such as schizophrenia and Huntington’s disease. Its high selectivity allows scientists to investigate the role of PDE10A in signal transduction pathways within the brain, particularly in the striatum, which is involved in motor control and cognition. Due to its pharmacological profile, it has been utilized in preclinical studies to assess the therapeutic potential of PDE10A inhibition on dopamine and glutamate signaling. It demonstrates good brain penetration and has been employed in animal models to evaluate effects on behavior, locomotor activity, and cognitive function.
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