Di-tert-butylchlorophosphine is primarily used as a precursor or reagent in the synthesis of organophosphorus compounds. It is particularly valuable in the preparation of phosphine ligands, which are essential in coordination chemistry and catalysis. These ligands are often employed in transition metal-catalyzed reactions, such as cross-coupling reactions, hydrogenation, and hydroformylation, due to their ability to stabilize metal centers and modulate reactivity. Additionally, this compound is utilized in the development of phosphorus-containing polymers and materials, which can have applications in flame retardants, adhesives, and coatings. Its sterically bulky tert-butyl groups make it useful for creating highly selective and sterically hindered phosphine derivatives, which are important in asymmetric synthesis and fine chemical production.