Bis(2-methoxyphenyl)phosphine oxide is primarily used in organic synthesis as a ligand or intermediate in the preparation of complex molecules. Its structure makes it suitable for coordinating with metals, which is valuable in catalytic processes, particularly in asymmetric synthesis where it can help control the stereochemistry of reactions. This compound is also explored in the development of advanced materials, such as polymers with specific optical or electronic properties, due to its ability to influence molecular interactions. Additionally, it finds application in pharmaceutical research for the synthesis of bioactive compounds, where its phosphine oxide group can enhance the stability or reactivity of intermediates.