(Methoxymethyl)diphenylphosphine oxide is utilized in organophosphorus chemistry, particularly for C-P bond formation reactions such as the Arbuzov or Michaelis-Becker reactions, which are essential for synthesizing organophosphorus compounds used in pesticides, catalysts, and pharmaceuticals. It serves as a key intermediate and precursor to phosphine ligands via reduction, enabling applications in transition metal catalysis, including cross-coupling reactions for complex organic molecules. Additionally, it is employed in the preparation of phosphine-based materials for organic electronics and optoelectronics, as well as in the development of flame retardants and stabilizers for polymers. Its role in asymmetric synthesis supports high enantioselectivity in catalytic processes through derived ligands.