Tri(o-tolyl)phosphine is widely used as a ligand in coordination chemistry, particularly in the synthesis of transition metal complexes. Its bulky structure makes it effective in stabilizing metal centers, which is crucial in catalytic processes such as cross-coupling reactions, including Suzuki and Heck reactions. It is also employed in the production of organometallic compounds, where it enhances reactivity and selectivity. Additionally, it finds use in the development of materials like phosphorescent dyes and OLEDs, where it contributes to the tuning of electronic properties. Its role in asymmetric synthesis further highlights its importance in creating chiral molecules for pharmaceuticals and fine chemicals.