Tris(4-fluorophenyl)phosphine is widely used as a ligand in coordination chemistry and catalysis, particularly in transition metal-catalyzed reactions. Its electron-withdrawing fluorine substituents enhance the stability and reactivity of metal complexes, making it valuable in cross-coupling reactions such as Suzuki-Miyaura and Heck reactions. It also finds application in the synthesis of organic semiconductors and optoelectronic materials due to its ability to modify electronic properties. Additionally, it serves as a precursor in the preparation of phosphine-based polymers and advanced materials for use in sensors and coatings. Its role in asymmetric catalysis further highlights its importance in producing chiral compounds for pharmaceuticals and fine chemicals.