2-(Diphenylphosphino)-2',4',6'-triisopropylbiphenyl is widely used as a ligand in transition metal catalysis, particularly in cross-coupling reactions. Its bulky structure enhances steric hindrance, improving the efficiency and selectivity of catalytic processes. This compound is especially valuable in palladium-catalyzed reactions, such as Suzuki-Miyaura and Buchwald-Hartwig couplings, where it facilitates the formation of carbon-carbon and carbon-nitrogen bonds. Its stability and electron-donating properties make it a preferred choice for synthesizing complex organic molecules in pharmaceuticals, agrochemicals, and advanced materials. Additionally, it is employed in asymmetric catalysis to produce chiral compounds with high enantiomeric purity.