AdCyBrettPhos is primarily used as a ligand in transition metal-catalyzed reactions, particularly in cross-coupling processes. Its application is significant in the synthesis of complex organic molecules, including pharmaceuticals and agrochemicals. The ligand enhances the efficiency and selectivity of palladium-catalyzed reactions, such as Buchwald-Hartwig amination, which is crucial for forming carbon-nitrogen bonds. This makes it valuable in the development of drug candidates and fine chemicals. Additionally, AdCyBrettPhos is employed in the preparation of biaryl compounds, which are essential intermediates in various organic syntheses. Its robust performance under challenging reaction conditions further broadens its utility in industrial and academic research settings.