Tris(3-fluorophenyl)phosphine is primarily used as a ligand in various catalytic processes, particularly in transition metal catalysis. It plays a significant role in facilitating cross-coupling reactions, such as Suzuki and Heck reactions, which are essential in the synthesis of complex organic compounds, including pharmaceuticals and agrochemicals. Its electron-withdrawing fluorine substituents enhance the stability and reactivity of the metal complexes formed, making it a valuable component in fine chemical synthesis. Additionally, it is employed in the development of advanced materials, including polymers and coordination compounds, where precise control over molecular structure and properties is required.