Sodium 2'-(dicyclohexylphosphino)-2,6-dimethoxy-[1,1'-biphenyl]-3-sulfonate is primarily used as a ligand in transition metal catalysis, particularly in palladium-catalyzed cross-coupling reactions. Its water-soluble nature makes it highly effective in aqueous-phase reactions, enabling environmentally friendly processes. This ligand is especially valuable in Suzuki-Miyaura and Heck couplings, where it enhances reaction efficiency and selectivity. Its application extends to pharmaceutical synthesis, where it facilitates the production of complex organic molecules with high precision. Additionally, it is utilized in the development of advanced materials and fine chemicals, showcasing its versatility in modern organic chemistry.