Used as a ligand in transition metal-catalyzed coupling reactions, particularly in palladium-catalyzed cross-coupling processes. Its electron-rich structure and steric bulk enhance catalytic efficiency and stability, leading to improved yields and selectivity in forming carbon-carbon and carbon-heteroatom bonds. Commonly applied in pharmaceutical synthesis and materials science where high catalyst performance is required. The trifluoromethyl group contributes to increased ligand stability and influences the electronic properties of the metal center, enabling reactions under milder conditions.