Used as a chiral ligand in asymmetric catalysis, particularly in rhodium- or ruthenium-catalyzed enantioselective hydrogenation reactions. It is highly effective in the synthesis of chiral pharmaceutical intermediates and fine chemicals due to its ability to induce high enantiomeric excess (ee). Its steric bulk and electron-withdrawing trifluoromethyl groups enhance catalyst stability and selectivity. Commonly applied in the production of optically active amino acids, amines, and other bioactive molecules where stereochemistry is critical.