Used as a chiral catalyst ligand in asymmetric synthesis, particularly in enantioselective transformations such as C–C bond-forming reactions. Its sterically hindered, electron-deficient structure enables high enantioselectivity and reactivity in transition metal-catalyzed processes, including palladium- and rhodium-catalyzed additions and cyclizations. Commonly applied in pharmaceutical and fine chemical synthesis where precise stereochemical control is critical. The trifluoromethyl groups enhance ligand stability and influence electronic properties, improving catalyst performance under demanding conditions.