Used as a chiral ligand in asymmetric catalysis, particularly in transition metal-catalyzed reactions such as hydrogenation and cross-coupling. Its phosphine group coordinates effectively with metals like rhodium, ruthenium, and palladium, enabling high enantioselectivity in the synthesis of pharmaceutical intermediates and fine chemicals. The steric bulk and electron-withdrawing trifluoromethyl groups enhance catalytic efficiency and stereochemical control. Commonly applied in the development of active pharmaceutical ingredients where precise chirality is critical for biological activity.