Used as a specialized ligand in palladium-catalyzed cross-coupling reactions, particularly in Buchwald–Hartwig amination, enabling efficient carbon–nitrogen bond formation. Its steric bulk and electron-rich phosphine group enhance catalyst stability and reactivity, allowing reactions to proceed under milder conditions with high selectivity. Commonly applied in the synthesis of pharmaceuticals, agrochemicals, and functional materials where precise C–N coupling is required. Also employed in the preparation of complex organic molecules, including heterocycles and natural product derivatives, due to its compatibility with a wide range of substrates and functional groups.