Used as a ligand in transition metal catalysis, particularly in palladium-catalyzed cross-coupling reactions. Its electron-rich phosphine group enhances catalyst stability and activity, while the trifluoromethylpyridine moiety improves solubility and electronic tuning. Commonly applied in Suzuki–Miyaura and Buchwald–Hartwig aminations for forming carbon–carbon and carbon–nitrogen bonds in pharmaceutical and agrochemical synthesis. Also employed in the development of homogeneous catalysts for asymmetric synthesis due to its ability to induce chirality when coordinated to metals.