Used as a ligand in transition metal-catalyzed reactions, particularly in palladium-catalyzed cross-coupling processes. Its electron-rich nature enhances catalyst stability and activity, improving yields in carbon–carbon and carbon–heteroatom bond formations. Applied in pharmaceutical synthesis where selective and efficient coupling is required. The difluoromethyl group can influence the ligand’s electronic properties and metabolic stability, making it suitable for fine chemical and medicinal chemistry applications.