Widely used as a ligand in palladium-catalyzed cross-coupling reactions, this phosphine compound plays a key role in forming carbon-carbon bonds, especially in the synthesis of complex organic molecules. It is particularly effective in Suzuki-Miyaura couplings, where it helps couple aryl halides with aryl boronic acids under mild conditions with high yields. Its steric bulk and electron-rich nature enhance catalyst stability and reactivity, making it suitable for coupling reactions involving sterically hindered substrates. It is also employed in pharmaceutical and agrochemical industries for constructing biaryl structures found in active ingredients. The ligand’s performance in low catalyst loadings makes it valuable for industrial-scale processes where efficiency and cost-effectiveness are critical.