Widely used as a ligand in palladium-catalyzed cross-coupling reactions, particularly in Suzuki-Miyaura coupling, enabling efficient carbon-carbon bond formation. Its steric bulk and electron-rich nature enhance catalytic activity and stability, making it valuable in synthesizing complex organic molecules such as pharmaceuticals, agrochemicals, and advanced materials. It is especially effective in coupling aryl chlorides, which are less reactive and more cost-effective substrates. The ligand’s performance in low catalyst loadings makes it suitable for industrial-scale applications where efficiency and cost savings are critical.