Widely used as a ligand precursor in palladium-catalyzed cross-coupling reactions, enabling efficient C–C and C–heteroatom bond formation under mild conditions. Its steric bulk and electron-rich nature enhance catalyst stability and reactivity, particularly in Buchwald–Hartwig aminations and Suzuki–Miyaura couplings. Commonly employed in the synthesis of pharmaceuticals, agrochemicals, and functional materials where high selectivity and turnover are required. The tetrafluoroborate counterion improves solubility in polar organic solvents, facilitating homogeneous catalysis. Also applied in asymmetric synthesis when paired with chiral catalysts, supporting the development of enantiomerically pure compounds.