Used as a ligand in palladium-catalyzed cross-coupling reactions, particularly in Buchwald–Hartwig amination and Suzuki–Miyaura coupling. Its steric bulk and electron-rich nature enhance catalyst stability and reactivity, enabling efficient C–N and C–C bond formation under mild conditions. Commonly applied in pharmaceutical synthesis and fine chemical manufacturing where high selectivity and functional group tolerance are required. Also effective in catalyzing reactions involving challenging substrates such as aryl chlorides.