Used as a ligand in transition metal catalysis, particularly in palladium-catalyzed cross-coupling reactions. Its phosphine group coordinates effectively with metals, enhancing catalytic activity and stability. Commonly applied in Buchwald–Hartwig aminations and Suzuki–Miyaura couplings for forming carbon–nitrogen and carbon–carbon bonds in pharmaceutical and agrochemical synthesis. The oxazine ring contributes to solubility and electronic modulation, improving reaction efficiency and selectivity under mild conditions.