Used as a highly effective ligand in homogeneous catalysis, particularly in palladium-catalyzed cross-coupling reactions. Its sterically bulky yet flexible phosphine groups enhance metal center stability and reactivity, improving catalytic efficiency and selectivity. Commonly applied in C–C and C–heteroatom bond formations, such as Suzuki–Miyaura and Buchwald–Hartwig aminations, where it supports high turnover numbers under mild conditions. Also employed in asymmetric synthesis when coordinated to chiral metal complexes, enabling enantioselective transformations in pharmaceutical and fine chemical manufacturing.